Purpose

The 08bdth /spotty maternal- effect mutant was isolated and mapped after a 4- generation crossing strategy. It was mapped on chromosome 2, by the use of simple sequence length polymorphic markers between markers z24206 and z17291. 

In this project, I will focus on narrowing the genetic and physical interval containing the gene by finding new genetic markers positioned closer to the mutation. These maps guide scientists to mnay genes that are believed to interact to bring about more common disorders of diseases. 

So...... This is essential because....

• 70% of protein- coding human genes are related to genes found in the zebrafish and 84% of genes that are known to be associated with human disease have a zebrafish counterpart. 
• Zebrafish and humans both share the characteristic of being vertebrates.
• Some zebrafish mutants are known to develop and duplicate certain conditions and diseases common to humans.